Full Project I
Full Project I: Identification of pro-inflammatory molecules involved in Areca nut carcinogenesis, by Jian Yang (UOG) and Reinhold Penner (UHCC). This project’s aim is to identify the active chemical components of Areca that mediate calcium signals in immunocytes and determine the molecular mechanisms by which calcium is mobilized in these cells.
Short description of the NIH U54 UOG/UH project “Identification of pro-inflammatory molecules involved in Areca nut carcinogenesis”
Around 600 million people worldwide consume Areca (betel) nut. Areca use is highly associated with oral carcinoma, oral pre-cancerous lesions, oral submucous fibrosis, and periodontal and inflammatory diseases. Betel nut consumption is a great concern in public health on Guam. The goal of this study is to identify and characterize pro-inflammatory molecules involved in Areca nut carcinogenesis. The objectives of the project are to (1) extract, identify, and characterize the active chemical components of Areca nuts that mediate calcium signals in immunocytes and (2) determine the mutagenicity of Areca nuts extracts and fractions separated by HPLC (high-performance liquid Chromatography).